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Perampanel Dosage

Available as tablets, perampanel is taken once a day at bedtime to help treat partial-onset seizures. Dosing usually starts at 2 mg a day. Your healthcare provider may slowly increase this amount based on how you respond to the drug. However, dose increases should not occur more often than once a week.

An Introduction to Your Dosage of Perampanel

The dose of perampanel (Fycompa™) your healthcare provider recommends will vary, depending on a number of factors, including:
  • Your age
  • How well your seizures are controlled
  • How well you tolerate the medication
  • Other medications you are taking
  • Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Recommended Perampanel Dosing Guidelines

The usual recommended initial dosage of perampanel for controlling partial seizures in people with epilepsy is 2 mg a day. This amount is normally slowly increased, as needed, in increments of 2 mg a day, no more often than once a week. In older adults and people with liver disease, however, increases should occur no more often than once every two weeks.
Most people will be treated with perampanel doses that range between 4 mg and 12 mg a day. The amount you end up taking will be individualized, based on how well your seizures are controlled and whether you experience side effects. In clinical trials, 12 mg a day was somewhat more effective at reducing seizures, but was also associated with more side effects.
People with liver disease may have higher blood levels of perampanel. Therefore, the maximum recommended dosage is 6 mg a day for people with mild liver disease and 4 mg a day for people with moderate liver disease. Perampanel is not recommended for use in people with severe liver disease. It is also not recommended for use in people with severe kidney disease.
Certain other anti-seizure medications can reduce blood levels of perampanel. This includes the medications carbamazepine (Carbatrol®, Epitol®, Equetro®, Tegretol®), oxcarbazepine (Trileptal®), oxcarbazepine extended-release (Oxtellar XR™), and phenytoin (Dilantin®, Phenytek®). The usual recommended starting dosage of perampanel in people who are taking these other medicines is 4 mg a day. This amount is then slowly increased, if needed, no more often than once a week.
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Perampanel Medication Information

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