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Orap Warnings and Precautions

Because Orap can cause potentially serious complications, this medication is reserved for use in people who have not responded to, or cannot take, certain other medications for Tourette syndrome. Some of the dangerous problems include a life-threatening heart rhythm problem and an irreversible movement disorder. People who have certain medical conditions should take Orap with caution and carefully review the safety warnings associated with this drug.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Orap® (pimozide) if you have:
  • Kidney disease, such as kidney failure (renal failure)
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • Heart rhythm problems (arrhythmias), including a condition known as congenital long QT syndrome
  • Been told you have electrolyte problems, such as low potassium or magnesium levels
  • Low white blood cell counts
  • A history of low white blood cells from taking another medication
  • A history of a seizure
  • Had an abnormal electroencephalography (EEG), a test that records the electrical activity of the brain
  • Had a tumor in your pituitary gland
  • Glaucoma
  • Alzheimer's disease or other types of dementia
  • Prostate problems, such as benign prostatic hypertrophy (BPH)
  • Problems with urination
  • Constipation or decreased gastrointestinal (bowel) motility (slowed movement of food through the intestinal tract)
  • A history of severe side effects to another antipsychotic medication
  • Parkinson's disease
  • Severe diarrhea, or believe you may be dehydrated
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
Know the Signs - Concussion Safety

Orap Medication Information

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