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What Are the Effects?

Three studies have shown that zonisamide is effective for treating partial seizures in adults whose seizures were not adequately controlled by other medications. In these studies, people added zonisamide or a placebo (a "sugar pill") to the seizure medications they were already taking. Those who added zonisamide decreased their rates of partial seizures by up to 40.5 percent, compared to just 9 percent in those who added the placebo to their medications.

When and How to Take Zonisamide

General considerations for when and how to take zonisamide include the following:
  • The medication comes in capsule form and is taken by mouth once or twice daily.
  • Usually, you will start with a low zonisamide dose and slowly increase up to an effective one.
  • Be sure to swallow the capsules whole (do not chew, crush, or open them).
  • Zonisamide can be taken with or without food. If the medication bothers your stomach, try taking it with food.
  • Zonisamide should be taken at the same time each day to maintain an even level in your blood.
  • For the medication to work properly, it must be taken as prescribed. Zonisamide will not work if you stop taking it.
  • Do not stop taking the drug without first discussing it with your healthcare provider (see Zonegran Withdrawal).

Dosing Information

The dose of zonisamide your healthcare provider recommends will vary, depending on a number of factors, including:
  • Other medications you may be taking (especially other seizure medications)
  • Other medical conditions you may have.
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
(Click Zonisamide Dosing for more information.)
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Zonisamide Drug Information

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