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You should talk with your healthcare provider prior to taking this medicine if you have:
- Heart problems of any kind, especially a history of heart disease, angina, an irregular heart rhythm (including Wolff-Parkinson-White syndrome), or a history of a heart attack
- High blood pressure (hypertension)
- High cholesterol
- Certain blood vessel conditions, such as peripheral vascular disease, ischemic bowel disease, or Raynaud's phenomenon
- A history of a stroke, transient ischemic attack (TIA or "mini-stroke"), or other bleeding in the brain (such as a subarachnoid hemorrhage)
- Liver problems, including liver failure or cirrhosis
- Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you:
- Are pregnant or thinking of becoming pregnant (see Zomig and Pregnancy)
- Are breastfeeding
- Have a family history of heart disease
- Have gone through menopause.
You should also tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Zolmitriptan for more information on this topic, including information on who should not take the drug.)
Zolmitriptan is part of a class of migraine medications called 5-HT agonists (or more commonly known as "triptans"). During a migraine headache, some of the blood vessels in the head become dilated (wider than they usually are). This medication works by narrowing these blood vessels, helping them return to their normal state. This action helps to relieve migraine symptoms.