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Drug Interactions With Zolmitriptan
Among the drugs that can potentially interact with zolmitriptan are other triptans, type A monoamine oxidase inhibitors (MAO-A inhibitors), and cimetidine. Drug interactions with zolmitriptan can increase your risk of dangerous side effects or cause a group of symptoms called serotonin syndrome (which can include confusion, muscle spasms, and sweating), among other things. Make sure to talk with your pharmacist or healthcare provider about any zolmitriptan drug interactions that may apply to you.
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Zolmitriptan (Zomig®) can potentially interact with a number of other medicines. Some of the medicines that may lead to zolmitriptan interactions include:
- Cimetidine (Tagamet®)
- Certain antidepressants or fibromyalgia medications, such as:
- Miscellaneous antidepressants, such as:
- Bupropion (Aplenzin™, Budeprion XL®, Budeprion™ SR, Buproban®, Wellbutrin SR®, Wellbutrin XL®, Wellbutrin®, Zyban®)
- Mirtazapine (Remeron®)
- Nefazodone (Serzone®)
- Trazodone (Desyrel®) or trazodone ER (Oleptro™)
- Vilazodone (Viibryd™)
- Monoamine oxidase inhibitors (MAOIs), such as:
- Isocarboxazid (Marplan®)
- Phenelzine (Nardil®)
- Rasagiline (Azilect®)
- Selegiline (Eldepryl®, Emsam®, Zelapar®)
- Tranylcypromine (Parnate®)
- Selective serotonin reuptake inhibitor (SSRI) or serotonin norepinephrine reuptake inhibitor (SNRI) medications, such as:
- Citalopram (Celexa®)
- Duloxetine (Cymbalta®)
- Desvenlafaxine (Pristiq®)
- Escitalopram (Lexapro®)
- Fluoxetine (Prozac®, Sarafem®, Selfemra™)
- Fluvoxamine (Luvox®, Luvox® CR)
- Milnacipran (Savella™)
- Paroxetine (Paxil®, Paxil CR®, Pexeva®)
- Sertraline (Zoloft®)
- Venlafaxine (Effexor®, Effexor XR®)
- Tricyclic antidepressants, such as:
- Amitriptyline (Elavil®)
- Amoxapine (Asendin®)
- Clomipramine (Anafranil®)
- Desipramine (Norpramin®)
- Doxepin (Sinequan®, Silenor®)
- Imipramine (Tofranil®, Tofranil PM®)
- Maprotiline (Ludiomil®)
- Nortriptyline (Pamelor®)
- Protriptyline (Vivactil®)
- Trimipramine (Surmontil®)
- Ergot medications, such as:
- Bromocriptine (Parlodel®)
- Dihydroergotamine (Migranal®)
- Ergotamine (Bellamine S®, Cafergot®, Ergomar®)
- Pergolide (Permax®)
- Triptans (other migraine medications similar to zolmitriptan), such as:
- Almotriptan (Axert®)
- Eletriptan (Relpax®)
- Frovatriptan (Frova®)
- Naratriptan (Amerge®)
- Rizatriptan (Maxalt®)
- Sumatriptan (Alsuma™, Imitrex®, Sumavel®, Zecuity™) or sumatriptan/naproxen sodium (Treximet®).
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD