Taking zolmitriptan with cimetidine can raise the amount of zolmitriptan in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to decrease your dose of zolmitriptan or may recommend a cimetidine alternative.

 

Taking zolmitriptan with certain depression medications, including selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), can cause a group of symptoms called serotonin syndrome. These symptoms may include confusion, hallucinations, a fast heartbeat, feeling faint, a fever, sweating, muscle spasms, difficulty walking, and diarrhea. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.

 

Taking zolmitriptan with ergot medications can increase your risk of dangerous side effects. Do not take zolmitriptan and ergot medications within 24 hours of each other.

 

Taking zolmitriptan with type A monoamine oxidase inhibitors can increase the amount of zolmitriptan in your blood, perhaps increasing your chance of side effects. Do not take zolmitriptan if you have used an MAO-A inhibitor within the last two weeks.

 

In previous studies, selegiline (a type B monoamine oxidase inhibitor) did not have any effect when taken with zolmitriptan. However, at higher doses, selegiline is also a type A monoamine oxidase inhibitor. Therefore, you should talk with your healthcare provider before taking selegiline and zolmitriptan together.