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Drug Interactions With Zolmitriptan

Zolmitriptan Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when zolmitriptan is combined with any of the drugs listed above.
Cimetidine (Tagamet)
Taking zolmitriptan with cimetidine can raise the amount of zolmitriptan in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to decrease your dose of zolmitriptan or may recommend a cimetidine alternative.
Certain Antidepressants
Taking zolmitriptan with certain depression medications can cause a group of symptoms called serotonin syndrome. These symptoms include:
  • Confusion
  • Hallucination
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.
Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.
There are special warnings for MAOIs. Taking zolmitriptan with a type A MAOI can greatly increase the amount of zolmitriptan in your blood, increasing your chance of dangerous side effects. Do not take zolmitriptan if you have used a type A MAOI within the last two weeks.
Although selegiline and rasagiline are usually considered to be type B MAOIs, they may also be MAO-A inhibitors when used at high doses. Ask your healthcare provider before taking zolmitriptan with selegiline or rasagiline.
Ergot Medications
Taking zolmitriptan with ergot medications can increase your risk of dangerous side effects. Do not take zolmitriptan and ergot medications within 24 hours of each other.
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Zolmitriptan (Zomig)

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