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Vigabatrin Side Effects

Common Side Effects in Adults and Older Children

Vigabatrin has been studied extensively in clinical trials. In these studies in adults and older children (age 10 and up), the side effects that occurred in a group of people taking vigabatrin were documented and compared to reactions that occurred in another group of people taking a placebo (a "sugar pill" that does not contain any active ingredients). As a result, it is possible to see what vigabatrin side effects occurred, how often they appeared, and how they compared to the group taking the placebo.
In these studies, the most common vigabatrin side effects in adults or older children (age 10 and up) included:
  • Fatigue -- in up to 40 percent of people
  • At least some degree of permanent vision loss -- in "at least 30 percent of people" (exact percentage was not provided)
  • Drowsiness -- up to 26 percent
  • Dizziness -- up to 26 percent
  • Irritability -- up to 23 percent
  • Involuntary eye movements -- up to 19 percent.
Other common side effects in adults or older children, occurring in 10 percent to 17 percent of people, included:
  • Blurred vision
  • Double vision
  • Diarrhea
  • Walking pattern "gait" changes
  • Weight gain
  • Shakiness (tremors)
  • Memory problems
  • Coordination problems
  • Depression
  • Confusion
  • Throat pain
  • Cough.
Some of these common side effects are also potentially serious and should be reported to your healthcare provider.
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