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Vigabatrin Dosage

What Is the Recommended Vigabatrin Dosage for Infantile Spasms?

The recommended starting dosage for treating infantile spasms in children one month to two years of age is based on the child's weight. The starting dosage is 25 mg per kg twice daily (about 11.4 mg per lb twice daily). Your child's healthcare provider may increase the amount every three days as necessary, up to a maximum of 75 mg per kg twice daily (about 34.1 mg per lb twice daily). Children with kidney problems may need lower-than-normal dosages.
 
Vigabatrin powder comes in 500-mg packets. Each packet is mixed with 10 mL of water to make a liquid with a concentration of 50 mg per mL. Make sure you know exactly how many packets to use per dose, how much water to add, and how much of this liquid to give your child.
 

General Information on Taking Vigabatrin

Some considerations to keep in mind during treatment with vigabatrin include the following:
 
  • Vigabatrin comes in tablet form or as a powder that is mixed with water to make a liquid. It is usually taken by mouth twice a day.
 
  • This medication can be taken with or without food.
 
  • For the powder form, empty the prescribed number of packets and add the prescribed amount of cold or room-temperature water (usually 10 mL of water per packet). After the medication is fully dissolved, measure the appropriate amount. If you do not need all of the medication for a dose, make sure to discard the remaining amount; do not save it for later.
 
  • For the medication to work properly, it must be taken as prescribed.
 
  • As with other seizure medications, do not stop taking vigabatrin without your healthcare provider's approval. When you stop taking this medication, it should usually be stopped gradually over a period of at least three weeks.
 
  • If you are unsure about anything related to your dosage or vigabatrin dosing in general, please talk with your healthcare provider or pharmacist.
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Vigabatrin Drug Information

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