Trihexyphenidyl Dosage

The usual starting trihexyphenidyl dosage for treating Parkinson's disease is 1 mg once daily. Your healthcare provider may gradually increase your dose up to a maximum of 15 mg per day until your symptoms are controlled. For the treatment of extrapyramidal symptoms due to antipsychotic medications, trihexyphenidyl dosing usually starts at 1 mg once daily. Your healthcare provider may also increase this dosage as needed.

 

Trihexyphenidyl Dosage: An Introduction

The dose of trihexyphenidyl hydrochloride (Artane®) that your healthcare provider recommends will vary, depending on a number of factors, including:
 
  • How you respond to trihexyphenidyl (especially if you develop side effects)
  • The medical condition being treated
  • Other medications you are taking
  • Other medical conditions you may have.
     
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
 

Trihexyphenidyl Dosing for Parkinson's Disease

The usual starting trihexyphenidyl dosage for treating Parkinson's disease is 1 mg once daily. Your healthcare provider may gradually increase your dose (by increments of 2 mg every three to five days) until your symptoms are controlled or up to a maximum of 15 mg total per day. Usually, it is recommended that the daily trihexyphenidyl dose be split up into three smaller doses taken at meals, or if higher doses are taken (more than 10 mg total per day), into four smaller doses per day, at meals and at bedtime.
 
Be aware that lower doses are often necessary when trihexyphenidyl is combined with levodopa products (such as Sinemet®, Sinemet® CR, Parcopa®, or Stalevo®).
 
(Trihexyphenidyl Dosage Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;