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Precautions and Warnings With Trihexyphenidyl
To help ensure safe treatment and minimize risks, talk to your healthcare provider about the precautions and warnings with trihexyphenidyl before starting the drug. Since trihexyphenidyl can worsen certain medical conditions, you should tell your healthcare provider about all existing conditions you have (including glaucoma, tachycardia, or high blood pressure). Also let him or her know if you are pregnant, breastfeeding, or taking other medications.
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You should talk with your healthcare provider prior to taking trihexyphenidyl hydrochloride (Artane®) if you have:
- Liver disease, such as liver failure, cirrhosis, or hepatitis
- Kidney disease, such as kidney failure (renal failure)
- Heart problems of any kind
- High blood pressure (hypertension)
- Glaucoma
- Difficulty passing urine
- An enlarged prostate (also known as benign prostatic hyperplasia or BPH)
- Tardive dyskinesia (a specific type of extrapyramidal symptoms due to antipsychotic medications)
- An alcohol problem
- A rapid heart rate (tachycardia)
- A job that requires you to do manual labor in the heat
- Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
- Pregnant or thinking of becoming pregnant
- Breastfeeding.
Make sure to tell your healthcare provider about any medications you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD



