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Precautions and Warnings With Trihexyphenidyl

Specific Warnings and Precautions for Trihexyphenidyl

Warnings and precautions to be aware of prior to taking trihexyphenidyl include the following:
  • Trihexyphenidyl can cause drowsiness, confusion, or other mental problems that may interfere with your ability to drive or operate heavy machinery.
  • Trihexyphenidyl can inhibit the body's ability to cool itself by sweating. This can lead to heat stroke, especially in hot weather. People with alcohol problems and people who work in the heat may be especially prone to heat stroke. Let your healthcare provider know if you think this may be a problem for you (as it can be quite dangerous).
  • Trihexyphenidyl can worsen (or even cause) glaucoma, bladder or prostate problems, or a rapid heart rate. If you have such problems, trihexyphenidyl may not be right for you.
  • Trihexyphenidyl should not be used to treat tardive dyskinesia, as it is not effective for this use. However, trihexyphenidyl may be used to treat other forms of extrapyramidal symptoms (EPS) in people who also have tardive dyskinesia, although it is possible that Trihexyphenidyl may worsen the tardive dyskinesia.
  • Trihexyphenidyl can cause hallucinations (seeing, hearing, or feeling things that are not really there) or other psychological problems. Let your healthcare provider know if you develop hallucinations while taking trihexyphenidyl.
  • Trihexyphenidyl can cause confusion, memory loss, or other Alzheimer's-like symptoms.
  • Sometimes people take trihexyphenidyl more often (or at higher doses) than prescribed in order to achieve euphoria or a "high." This can lead to problems due to the high trihexyphenidyl dosage. Be open and honest with your healthcare provider about your trihexyphenidyl usage, as misusing trihexyphenidyl may be a sign of depression or other mental problems.
  • Make sure your healthcare provider knows if you have heart problems, kidney disease, liver disease, or high blood pressure. Although you can still take trihexyphenidyl, your healthcare provider may want to monitor you more closely.
  • Trihexyphenidyl can potentially interact with several medications (see Drug Interactions With Trihexyphenidyl).
  • Trihexyphenidyl is usually considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not known (see Artane and Pregnancy).
  • It is not known whether trihexyphenidyl passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Artane and Breastfeeding).
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Trihexyphenidyl Hydrochloride Information

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