Tolcapone (Cont.)

Drug Interactions With Tolcapone

Tolcapone can potentially interact with a number of other medicines (see Drug Interactions With Tolcapone).
 

What If I Take an Overdose of Tolcapone?

It is not known exactly what to expect from an overdose with tolcapone, although some studies suggest that taking too much may cause the following symptoms:
 
  • Nausea
  • Vomiting
  • Dizziness
  • Difficulty breathing.
     
If you happen to take too much tolcapone, seek immediate medical attention.
 
(Click Tasmar Overdose for more information.)
 

How Should Tolcapone Be Stored?

Tolcapone tablets should be stored at room temperature, away from moisture, heat, and light. Keep tolcapone and all other medications out of the reach of children.
 

What Should I Do If I Miss a Dose of Tolcapone?

If you forget to take a dose of tolcapone, take your missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose.
 

How Does Tolcapone Work?

Tolcapone is always used in combination with carbidopa and levodopa; it is not effective at treating Parkinson's disease when used alone. The drug works by increasing blood levels of levodopa and helping it last longer in the body. Tolcapone works by inhibiting an enzyme known as catechol-O-methyltransferase (COMT) that breaks down levodopa before it has a chance to reach the brain.
 
(Tolcapone Continued: Page 4)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;