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Drug Interactions With Teriflunomide

More Detail on Drug Interactions With Teriflunomide

The following sections explain in detail the potentially negative reactions that can occur when teriflunomide is combined with any of the drugs listed above.
 
Alosetron
Teriflunomide may lower blood levels of alosetron, potentially making it less effective. Your healthcare provider may need to monitor you more closely if you take these medications together.
 
Bile Acid Sequestrants
Taking bile acid sequestrants with teriflunomide may decrease the amount of teriflunomide in your blood, possibly decreasing its effectiveness. In fact, cholestyramine (a bile acid sequestrant) is used to decrease teriflunomide blood levels when quick removal of the drug from the body is necessary, such as in cases of a teriflunomide overdose. You should generally avoid taking these medications together, unless your healthcare provider tells you otherwise.
 
Duloxetine
Teriflunomide may lower blood levels of duloxetine, potentially making it less effective. Your healthcare provider may need to monitor you more closely if you take these medications together to make sure duloxetine is working for you. 
 
Leflunomide
Leflunomide is converted in the body into teriflunomide, the active drug in teriflunomide. Taking these medications together would increase your blood levels of teriflunomide, and increase your risk for potentially serious side effects. These medications should not be taken together. 
 
Live Vaccinations
Live vaccines are vaccines that contain live viruses or bacteria. Teriflunomide may increase the risk that you could become infected with the virus or bacteria contained in a live vaccine. Also, live vaccines may be less effective in people taking teriflunomide.
 
It is generally recommended that you not receive live vaccinations during teriflunomide treatment, and for at least six months after treatment ends. Talk to your healthcare provider about which vaccines may be safe for you to receive during teriflunomide treatment.
 
Other Medications That Affect the Immune System
Taking teriflunomide with other medications that affect the immune system, including anticancer medications or other multiple sclerosis medications, could potentially increase your risk for side effects, such as low white blood cell counts and infections. Talk to your healthcare provider before taking teriflunomide with another immunosuppressant medication. In some cases, these medicines should not be used together. In other cases you may need close monitoring of your blood cell counts. 
 
Oral Contraceptives
Teriflunomide may increase blood levels of oral contraceptives, which could increase your risk for side effects. Talk to your healthcare provider if you take birth control pills during teriflunomide treatment, and if you are having particularly bothersome birth control pill side effects. Your healthcare provider may be able to switch you to an oral contraceptive that is more tolerable.
 
Paclitaxel
Teriflunomide may increase blood levels of paclitaxel, potentially increasing your risk for paclitaxel side effects. Your healthcare provider may choose to monitor you more closely if you take these medications together.
 
Pioglitazone
Teriflunomide may increase blood levels of pioglitazone, which could increase your risk for pioglitazone side effects. Your healthcare provider may choose to monitor you more closely if you take these medications together.
 
Repaglinide
Teriflunomide may increase blood levels of repaglinide, potentially increasing your risk for repaglinide side effects. Your healthcare provider may need to monitor you more closely if you take these medications together.
 
Rosiglitazone
Teriflunomide may increase blood levels of rosiglitazone, which could increase your risk for rosiglitazone side effects. Your healthcare provider may choose to monitor you more closely if you take these medications together.
 
Sipuleucel-T
Combining teriflunomide with sipuleucel-T may decrease the effectiveness of sipuleucel-T. This is because sipuleucel-T works by stimulating the body's immune system, while teriflunomide decreases the activity of the immune system. Talk with your healthcare provider before taking these medications together, as you may need to be monitored more closely.
 
Theophylline
Teriflunomide may lower blood levels of theophylline, potentially making it less effective. Your healthcare provider may need to monitor you more closely if you take these medications together.
 
Tizanidine
Teriflunomide may lower blood levels of tizanidine, which could make it less effective. Your healthcare provider may need to monitor you more closely if you take these medications together.
 
Warfarin
Teriflunomide may decrease blood levels of warfarin, potentially making the drug less effective. If you take warfarin, your healthcare provider may need to monitor your international normalized ratio (INR) more closely, especially when you start, stop, or have a change in your teriflunomide dose.
 
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Teriflunomide Drug Information

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