A few precautions and warnings with sumatriptan include potential drug interactions, the risk of an increase in blood pressure or a heart attack in some people taking sumatriptan, and the safety of taking the drug while pregnant or nursing. Also, there are some conditions that you should let your healthcare provider know about before taking sumatriptan, such as diabetes, depression, and high cholesterol. Among the people who should not take sumatriptan are those with untreated high blood pressure or severe liver problems.

• Heart problems of any kind, especially a history of heart disease, angina, an irregular heart rhythm, or a heart attack
• A history of stroke, transient ischemic attack (TIA or "mini-stroke"), or other bleeding in the brain (such as a subarachnoid hemorrhage)
• High blood pressure (hypertension)
• High cholesterol
• Diabetes
• Certain blood vessel conditions, such as peripheral vascular disease, ischemic bowel disease, or Raynaud's phenomenon
• Kidney problems, including kidney failure (renal failure)
• Liver problems, including liver failure or cirrhosis
• A history of seizures
• Epilepsy
• Depression
• Any allergies, including allergies to foods, dyes, or preservatives.
   

• Are pregnant or thinking of becoming pregnant
• Are breastfeeding
• Smoke
• Have a family history of heart disease
• Have gone through menopause.