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Drug Interactions With Rizatriptan

Rizatriptan Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when rizatriptan is combined with any of the drugs listed above.
Certain Antidepressants
Taking rizatriptan with certain depression medications can cause a group of symptoms called serotonin syndrome. These symptoms include:
  • Confusion
  • Hallucination
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.
Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.
There are special warnings for MAOIs. Taking rizatriptan with a type A MAOI can greatly increase the amount of rizatriptan in your blood, increasing your chance of dangerous rizatriptan side effects. Do not take rizatriptan if you have used a type A MAOI within the last two weeks. Although selegiline and rasagiline are usually considered to be type B MAOIs, they may also be MAO-A inhibitors when used at high doses. Ask your healthcare provider before taking rizatriptan with selegiline or rasagiline.
Ergot Medications
Taking rizatriptan with ergot medications can increase your risk of dangerous side effects. Do not take rizatriptan and ergot medications within 24 hours of each other.
Propranolol (Inderal, Inderal LA, InnoPran XL)
Taking rizatriptan with propranolol can increase the level of rizatriptan in your blood. People taking propranolol should not take more than rizatriptan 5 mg per dose.
Taking rizatriptan with other triptans can increase your risk of serious side effects. These medications should not be taken within 24 hours of each other.
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Rizatriptan (Maxalt)

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