Drug Interactions With Rizatriptan

The following sections explain in detail the potentially negative interactions that can occur when rizatriptan is combined with any of the drugs listed above.

 

Taking rizatriptan with certain antidepressants or fibromyalgia medications, including selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), can cause a group of symptoms called serotonin syndrome. Some of these symptoms include confusion, hallucinations, a fast heartbeat, feeling faint, a fever, sweating, muscle spasms, difficulty walking, and diarrhea. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.

 

Taking rizatriptan with ergot medications can increase your risk of dangerous side effects. Do not take rizatriptan and ergot medications within 24 hours of each other.

 

Taking rizatriptan with MAOIs can increase the amount of rizatriptan in your blood, perhaps increasing your chance of side effects. Do not take rizatriptan if you have used an MAOI within the last two weeks.

 

Taking rizatriptan with propranolol can increase the level of rizatriptan in your blood. People taking propranolol should not take more than rizatriptan 5 mg per dose.

 

Taking rizatriptan with other triptans can increase your risk of serious side effects. These medications should not be taken within 24 hours of each other.