Drug Interactions With Rizatriptan (Cont.)

Rizatriptan Interactions Explained

 
Certain Antidepressants
Taking rizatriptan with certain antidepressants, including selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), can cause a group of symptoms called serotonin syndrome. Some of these symptoms include confusion, hallucinations, a fast heartbeat, feeling faint, a fever, sweating, muscle spasms, difficulty walking, and diarrhea. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.
 
Ergot Medications
Taking rizatriptan with ergot medications can increase your risk of dangerous side effects. Do not take rizatriptan and ergot medications within 24 hours of each other.
 
Monoamine Oxidase Inhibitors (MAOIs)
Taking rizatriptan with MAOIs can increase the amount of rizatriptan in your blood, perhaps increasing your chance of side effects. Do not take rizatriptan if you have used an MAOI within the last two weeks.
 
Propranolol (Inderal, Inderal LA, InnoPran XL)
Taking rizatriptan with propranolol can increase the level of rizatriptan in your blood. People taking propranolol should not take more than rizatriptan 5 mg per dose.
 
Triptans
Taking rizatriptan with other triptans can increase your risk of serious side effects. These medications should not be taken within 24 hours of each other.
 

Final Thoughts on Drug Interactions With Rizatriptan

It is possible that not every rizatriptan drug interaction was discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about specific drug interactions with rizatriptan that may apply to you.
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;