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What Is Rasagiline Used For?

How Does Rasagiline Work?

Rasagiline belongs to a class of medications called monoamine oxidase inhibitors (MAOIs).
Dopamine deficiency, caused by a loss of dopamine-producing cells in certain parts of the brain, may be responsible for many of the symptoms of Parkinson's. An enzyme called monoamine oxidase (MAO) breaks down monoamine chemicals, including dopamine. By inhibiting MAO enzymes, rasagiline helps increase the amount of dopamine the brain can use, which helps relieve symptoms of Parkinson's disease.
There are two types of MAO: type A and B. Although there is some MAO-A in the brain, it is found primarily in the digestive tract. MAO-B is the main form in the brain and is also found in blood platelets. Although rasagiline is "selective" for MAO-B, it does inhibit MAO-A to some extent, especially at higher doses. Unfortunately, MAO-A is responsible for breaking down dietary tyramine, an amino acid that affects blood pressure. Any medication that inhibits MAO-A stops the body's ability to break down tyramine and can cause a person's tyramine levels to be too high, which can be extremely dangerous. Because tyramine is found in many foods and beverages, people taking MAOI medications (including rasagiline) must follow a strict diet (see Azilect Food Interactions for more information).

Is Rasagiline Used in Children?

Rasagiline is not approved for use in children. This makes sense, since Parkinson's disease is not likely to occur in children.

Is Rasagiline Used for Off-Label Reasons?

On occasion, your healthcare provider may recommend rasagiline for something other than Parkinson's disease. This is known as an "off-label" use. At this time, there are no universally accepted off-label rasagiline uses.
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