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Rasagiline: What Should I Tell My Healthcare Provider?

Talk with your healthcare provider prior to taking rasagiline if you have:
  • Liver disease, such as liver failure, hepatitis, or cirrhosis
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Rasagiline to learn more, including information on who should not take the drug.)

How Does Rasagiline Work?

Rasagiline belongs to a class of medications called monoamine oxidase inhibitors (MAOIs).
Dopamine deficiency, caused by a loss of dopamine-producing cells in certain parts of the brain, may be responsible for many of the symptoms of Parkinson's disease. An enzyme called monoamine oxidase (MAO) breaks down monoamine chemicals, including dopamine. By inhibiting MAO enzymes, rasagiline helps to increase the amount of dopamine that the brain can use, which helps relieve symptoms of Parkinson's disease.
There are two types of MAO: type A and B. Although there is some MAO-A in the brain, it is found primarily in the digestive tract. MAO-B is the main form in the brain and is also found in blood platelets. Although rasagiline is "selective" for MAO-B, it does inhibit MAO-A to some extent, especially at higher doses.
Unfortunately, MAO-A is responsible for breaking down dietary tyramine, an amino acid that affects blood pressure. Any medication that inhibits MAO-A stops the body's ability to break down tyramine and can cause a person's tyramine levels to be too high, which can be extremely dangerous. Because tyramine is found in many foods and beverages, people taking MAOI medications (including rasagiline) must follow a strict diet (see Azilect Food Interactions for more information).
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