The recommended rasagiline dosage is 1 mg once daily for people who are not taking any other Parkinson's disease medications. If you are already taking other medications for Parkinson's disease, the starting recommended dose is 0.5 mg once daily. If your symptoms do not improve, your healthcare provider may increase your rasagiline dose to 1 mg once daily.
The dose of rasagiline mesylate (Azilect®) your healthcare provider recommends will vary, depending on a number of factors, including:
- Other medications you are taking
- Other medical conditions you may have.
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
The recommended rasagiline dosage for people not taking any other Parkinson's disease medications is rasagiline 1 mg once daily.
If you are already taking other Parkinson's medications (especially levodopa medications, such as Sinemet®, Sinemet® CR, Parcopa®, or Stalevo®), the starting recommended dose is lower: rasagiline 0.5 mg once daily. If necessary, your healthcare provider may increase the dose to rasagiline 1 mg once daily in order to help control your Parkinson's disease symptoms. People who add rasagiline to a levodopa medication often will need to use a lower levodopa dosage, especially if side effects occur. Your healthcare provider will determine when (and if) you need to lower your levodopa dosage.
For people with mild liver disease, the maximum dose of rasagiline is 0.5 mg once daily. The medication is not recommended for people with moderate or severe liver disease.
For people taking certain medications that increase the level of rasagiline in the blood, the maximum recommended rasagiline dosage is 0.5 mg daily. These medications include:
- Ciprofloxacin (Cipro®, Cipro® XR, Proquin® XR)
- Ketoconazole (Nizoral®)
- Methoxsalen (8-MOP®, Oxsoralen®, Oxsoralen-Ultra®, Uvadex®)
- Mexiletine (Mexitil®)
- Norfloxacin (Noroxin®)
- Ofloxacin (Floxin®)
- Thiabendazole (Mintezol®).
(Click Drug Interactions With Rasagiline for more information.)