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Drug Interactions With Phenytoin

Rifampin
Phenytoin may make rifampin less effective. If you are taking these drugs together, your healthcare provider may need to increase your rifampin dosage.
 
Salicylates
Salicylates can raise the amount of phenytoin in your blood, increasing your risk of side effects. Your healthcare provider may need to measure the level of phenytoin in your blood and adjust your dose as necessary.
 
Sertraline
Sertraline may increase phenytoin levels in the blood, and phenytoin may make sertraline less effective. Check with your healthcare provider before taking these medications together.
 
Simvastatin
Phenytoin may decrease the level of simvastatin in your bloodstream, perhaps making it less effective. While this is not a particularly dangerous interaction, your healthcare provider may want to monitor your cholesterol levels to make sure simvastatin remains effective for you.
 
St. John's Wort
St. John's wort may make phenytoin less effective. Check with your healthcare provider before combining phenytoin with this supplement.
 
Sucralfate 
Sucralfate can decrease the amount of phenytoin in your blood, perhaps making it less effective. If you are taking these drugs together, your healthcare provider may need to measure your phenytoin level (using a blood test) and adjust your dose as necessary.
 
Sulfonamides
Sulfonamides can raise the amount of phenytoin in your blood, increasing your risk of side effects. Your healthcare provider may need to measure the level of phenytoin in your blood and adjust your dose as necessary.
 
Ticlopidine 
Ticlopidine can raise the amount of phenytoin in your blood, increasing your risk of side effects. Your healthcare provider may need to measure the level of phenytoin in your blood and adjust your dose as necessary.
 
Theophylline
Phenytoin can make theophylline less effective. If you are taking these drugs together, your healthcare provider may need to increase your theophylline dosage.
 
Tolbutamide 
Tolbutamide can raise the amount of phenytoin in your blood, increasing your risk of side effects. Your healthcare provider may need to measure the level of phenytoin in your blood and adjust your dose as necessary.
 
Trazodone 
Trazodone can raise the amount of phenytoin in your blood, increasing your risk of side effects. Your healthcare provider may need to measure the level of phenytoin in your blood and adjust your dose as necessary.
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Phenytoin Sodium

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