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Drug Interactions With Phenytoin

Omeprazole
Omeprazole may increase the level of phenytoin in the bloodstream. Check with your healthcare provider before taking these medications together. Be aware that some nonprescription medications contain omeprazole.
 
Paroxetine 
Phenytoin may make paroxetine less effective. If you are taking these drugs together, your healthcare provider may need to increase your paroxetine dosage.
 
Phenothiazines
Phenothiazines can raise the amount of phenytoin in your blood, increasing your risk of side effects. Your healthcare provider may need to measure the level of phenytoin in your blood and adjust your dose as necessary.
 
Praziquantel
Phenytoin may decrease the level of praziquantel in the bloodstream, perhaps making it less effective. Check with your healthcare provider before taking these drugs together.
 
Protease Inhibitors
Phenytoin may decrease the level of some protease inhibitors in the blood. Some protease inhibitors may decrease the level of phenytoin in the blood. Make sure to discuss this with your healthcare provider before taking these drugs together.
 
Quetiapine
Phenytoin may make quetiapine less effective. Check with your healthcare provider before taking these drugs together.
 
Quinidine
Phenytoin may make quinidine less effective. If you are taking these drugs together, your healthcare provider may need to increase your quinidine dosage.
 
Reserpine
Reserpine can decrease the amount of phenytoin in your blood, perhaps making it less effective. If you are taking these drugs together, your healthcare provider may need to measure your phenytoin level (using a blood test) and adjust your dose as necessary.
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Phenytoin Sodium

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