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Drug Interactions With Phenytoin

Chemotherapy Medications
Many chemotherapy medications, including both oral and IV ones, interact with phenytoin. Some increase the level of phenytoin, while others decrease phenytoin levels. In addition, phenytoin may make certain chemotherapy medications less effective. Always check with your healthcare provider before combining phenytoin with any chemotherapy drugs.
 
Chloramphenicol
Chloramphenicol can raise the level of phenytoin in your blood, increasing your risk of side effects. Your healthcare provider may need to measure the level of phenytoin in your blood and adjust your dose as necessary.
 
Chlordiazepoxide 
Chlordiazepoxide can raise the level of phenytoin in your blood, increasing your risk of side effects. Your healthcare provider may need to measure the level of phenytoin in your blood and adjust your dose as necessary.
 
Corticosteroids
Phenytoin may make corticosteroids less effective. If you are taking these drugs together, your healthcare provider may need to increase your corticosteroid dosage.
 
Cyclosporine
Phenytoin may make cyclosporine less effective. If you are taking these drugs together, your healthcare provider may need to monitor your cyclosporine levels and perhaps increase your cyclosporine dosage.
 
Delavirdine
Phenytoin and delavirdine should not be taken together, as combining them may make delavirdine less effective and may increase the risk of developing resistance to delavirdine or other similar HIV drugs.
 
Diazepam 
Diazepam can raise the amount of phenytoin in your blood, increasing your risk of side effects. Your healthcare provider may need to measure the level of phenytoin in your blood and adjust your dose as necessary.
Know the Signs - Concussion Safety

Phenytoin Sodium

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