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Perampanel Side Effects

When perampanel was given to people during clinical trials, some of the most common reactions included dizziness, headaches, and fatigue. Fortunately, most people who use this anti-seizure drug tolerate it fairly well. Serious side effects with perampanel are possible, however, and may include problems like severe dizziness, depression, and thoughts of suicide.


An Introduction to Side Effects of Perampanel

Just like any medicine, perampanel (Fycompa™) can cause side effects. However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If reactions do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with perampanel. Your healthcare provider can discuss a more complete list with you.)

Serious Perampanel Side Effects

Some side effects of perampanel are potentially serious and should be reported to your healthcare provider right away. These include but are not limited to:
  • Thoughts about suicide or harming yourself or attempts to harm yourself or others (see Seizure Medications and Suicide)
  • Depression that is new or worse
  • Anxiety that is new or worse
  • Agitation, anger, or irritability
  • Aggressive, hostile, or violent behaviors
  • Any unusual changes in your mood, thoughts, personality, or behavior
  • Feeling suspicious of others, believing things that are not real, or feeling that others are out to get you
  • Difficulty sleeping
  • Extreme happiness or excessive talkativeness
  • Severe drowsiness or fatigue
  • Problems with muscle coordination, balance, or walking
  • Severe or persistent dizziness or lightheadedness
  • Falls
  • Excessive weight gain
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching, flaking, or peeling of the skin
    • Unexplained swelling, especially of the face, lips, or throat
    • Difficulty swallowing or breathing.
Know the Signs - Concussion Safety

Perampanel Medication Information

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