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Perampanel Side Effects

Common Side Effects

Perampanel has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people taking the drug were carefully documented and compared to those that occurred in a similar group of people taking a placebo (a "sugar pill" with no active ingredients). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the placebo.
In these studies, the most common perampanel side effects included:
  • Dizziness -- in up to 43 percent of people
  • Sleepiness -- up to 18 percent
  • Headache -- up to 13 percent
  • Fatigue -- up to 12 percent
  • Irritability -- up to 12 percent
  • Falls -- up to 10 percent
  • Nausea -- up to 8 percent
  • Loss of muscle coordination -- up to 8 percent
  • Balance problems -- up to 5 percent
  • A whirling or spinning sensation (vertigo) -- up to 5 percent
  • Back pain -- up to 5 percent.
Other common reactions, occurring in 2 percent to 4 percent of people, included:
  • Weight gain
  • Blurred vision
  • Vomiting
  • Upper respiratory tract infections, such as the common cold
  • Difficulty speaking
  • Problems with walking
  • Anxiety
  • Excessive daytime sleepiness or prolonged nighttime sleep
  • Double vision
  • Constipation
  • Head injury, which was likely related to falls
  • Muscle or joint pain
  • Arm or leg pain
  • Reduced sense of touch
  • Aggression
  • Anger
  • Memory problems
  • Confusion
  • Loss of strength and energy
  • Bruising
  • Swelling of the arms, hands, legs, ankles, or feet
  • Injury to an arm or leg, which was likely related to falls
  • Skin cuts, which were likely related to falls
  • Pain in the back of the throat
  • Low blood sodium levels (hyponatremia)
  • Abnormal coordination
  • Tickling, tingling, burning, pricking, or numbness of the skin
  • Inappropriately elevated mood
  • Any changes in mood.
Know the Signs - Concussion Safety

Perampanel Medication Information

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