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How Does It Work?

Seizures are the result of brief abnormal activity in the brain's electrical system. It is not exactly known how perampanel works to treat seizures. The drug is thought to work by blocking the action of a chemical in the brain known as glutamate. Glutamate is the main excitatory chemical in the brain -- that is, it can excite brain neurons, causing them to fire rapidly.
By blocking the action of glutamate, perampanel stops this rapid firing of neurons and prevents the spread of abnormal electrical activity throughout the brain. This action is thought to prevent seizures from occurring.

When and How to Take This Medicine

Some general considerations to keep in mind during treatment with perampanel include the following:
  • Perampanel comes in the form of a tablet. It is usually taken by mouth once a day at bedtime.
  • You can take your dose with or without food. Try taking the medicine with food if it upsets your stomach.
  • Take your dose at about the same time each day to keep an even level of the drug in your bloodstream. 
  • For perampanel to work properly, it must be taken as prescribed. This medication will not work if you stop taking it.

Dosing Information for Perampanel

The dose of perampanel your healthcare provider recommends will vary, depending on a number of factors, including:
  • Your age
  • How well your seizures are controlled
  • How well you tolerate the medication
  • Other medications you are taking
  • Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
(Click Perampanel Dosage for more information.)
Know the Signs - Concussion Safety

Perampanel Medication Information

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