Nervous System Channel
Topics
Medications
Quicklinks
Related Channels

Drug Interactions With Perampanel

More Detail on Drug Interactions With Perampanel

The following sections explain in detail the potentially negative interactions that can occur when perampanel is combined with any of the drugs listed above.
 
Aminoglutethimide
Aminoglutethimide can decrease blood levels of perampanel, potentially making it less effective. These medications should generally not be used together if at all possible.
 
Aripiprazole
Perampanel may decrease blood levels of aripiprazole, potentially making it less effective. Your healthcare provider may choose to increase your aripiprazole dosage if you take these medications together.
 
Bosentan
Bosentan can decrease blood levels of perampanel, potentially making it less effective. These medications should generally not be used together if at all possible.
 
Dexamethasone
Dexamethasone can decrease blood levels of perampanel, potentially making it less effective. These drugs should generally not be used together if at all possible.
 
Certain Other Anti-Seizure Medicines
Certain other anti-seizure medications (anti-epileptics) can decrease blood levels of perampanel. Your healthcare provider may choose to start you on a higher perampanel dosage (4 mg a day) if you are taking one of these other anti-seizure drugs, particularly carbamazepine, oxcarbazepine, or phenytoin. Your healthcare provider will monitor you closely and adjust your dose as needed.
 
Certain Anti-Infectives
The anti-infective medicines (antibiotics) listed above may decrease blood levels of perampanel, potentially making it less effective. These drugs should generally not be used with perampanel. The manufacturer of perampanel specifically recommends it not be taken with rifampin.
 
Medications That Cause Drowsiness
Perampanel can cause significant drowsiness. Taking it with other medicines that cause drowsiness can add to these effects. It is safest to not take these drugs together. If you must take them together, do not drive or operate machinery until you know how these medicines affect you. In addition, taking perampanel with alcohol appears to increase the risk for unusual mood changes, such as anger, confusion, or depression. You should not drink alcohol during treatment.
 
Non-Nucleoside Reverse Transcriptase Inhibitors
NNRTIs may decrease blood levels of perampanel, potentially making it less effective. These medications should generally not be used together if possible. 
 
Oral Contraceptives
Perampanel can make oral contraceptives less effective, in particular oral contraceptives that contain levonorgestrel. This could increase your risk for an unintentional pregnancy. Women taking perampanel who do not desire to become pregnant should use nonhormonal methods of birth control.
 
St. John's Wort
St. John's wort can decrease blood levels of perampanel, potentially making it less effective. The manufacturer of perampanel recommends that St. John's wort not be used during treatment. 
 
Know the Signs - Concussion Safety

Perampanel Medication Information

Terms of Use
Advertise with Us
Contact Us
About eMedTV
Privacy Policy
Copyright © 2006-2017 Clinaero, Inc.
eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.