Drug Interactions With Oxcarbazepine Extended-Release
The following sections explain in detail the potentially negative reactions that can occur when oxcarbazepine extended-release is combined with any of the drugs listed above.
Oxcarbazepine extended-release may decrease blood levels of aripiprazole, potentially making it less effective. Your healthcare provider may choose to increase your aripiprazole dose if you take these medications together.
Calcium Channel Blockers
Oxcarbazepine extended-release can decrease blood levels of calcium channel blocker medicines, potentially making them less effective. Your healthcare provider may need to increase your calcium channel blocker dosage if you take oxcarbazepine extended-release with a calcium channel blocker.
Certain Other Anti-Seizure Medicines
Certain other anti-seizure medications (antiepileptics) can decrease blood levels of oxcarbazepine extended-release. Your healthcare provider may choose to start you on a higher oxcarbazepine extended-release dose (900 mg a day) if you take it in combination with carbamazepine, phenobarbital, or phenytoin. Your dose will then be slowly increased as needed. If you take oxcarbazepine extended-release with valproate medicines, your healthcare provider may need to monitor you more closely and increase your oxcarbazepine extended-release dosage if needed.
Oxcarbazepine extended-release can decrease the level of cyclosporine in your blood, which could make it less effective. If you take oxcarbazepine extended-release with cyclosporine, your healthcare provider may need to adjust your cyclosporine dosage.
Medications That Can Reduce Blood Sodium Levels
Oxcarbazepine extended-release can cause the level of sodium in your blood to be low, which could cause potentially serious side effects. Other medications that also decrease blood sodium levels may add to this effect. Many medications have the potential to cause low blood sodium levels; therefore, make sure your healthcare provider knows about all the medicines you are taking.
Oxcarbazepine extended-release can make oral contraceptives less effective, increasing your risk for unintentional pregnancy. It is recommended that nonhormonal methods of birth control be used during treatment with oxcarbazepine extended-release.