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Orap Drug Interactions

CYP 3A4 Inhibitor Medications
The liver breaks down Orap using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining Orap with one of these drugs may increase the level of Orap in your bloodstream, increasing your risk for dangerous side effects. In general, Orap should not be used with these medications.
Macrolide Antibiotics
In general, Orap should not be used with the group of antibiotics known as macrolide antibiotics, as this combination can increase the risk for a potentially dangerous change in the heart rhythm known as QT prolongation.
QT-Prolonging Medications
Because Orap can cause QT prolongation (a potentially dangerous change in the heart rhythm), it should generally not be combined with any other drug that can cause QT prolongation. The combination increases the risk of a life-threatening arrhythmia.
Medications That Cause Drowsiness
You could become excessively drowsy if you take Orap in combination with other medications that can cause drowsiness. This could make it unsafe to perform tasks that require mental alertness, such as driving.
Because methylphenidate can cause physical movements that resemble tics, it should not be used in people who are taking Orap.

Final Thoughts

It is possible that not all Orap drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific interactions that may apply to you.
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Orap Medication Information

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