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Orally Disintegrating Selegiline

How Does Orally Disintegrating Selegiline Work?

Orally disintegrating selegiline belongs to a class of medications called monoamine oxidase inhibitors (MAOIs).
A dopamine deficiency, caused by a loss of dopamine-producing cells in certain parts of the brain, may be responsible for many of the symptoms of Parkinson's disease. An enzyme called monoamine oxidase (MAO) breaks down monoamine chemicals, including dopamine. By inhibiting MAO enzymes, orally disintegrating selegiline helps increase the amount of dopamine that the brain can use, which helps relieve symptoms of Parkinson's disease.
There are two types of MAO: type A and B. MAO-B is the main form in the brain and is also found in blood platelets. Although there is some MAO-A in the brain, it is found primarily in the digestive tract. MAO-A is responsible for breaking down dietary tyramine, an amino acid that affects blood pressure. Any medication that inhibits MAO-A stops the body's ability to break down tyramine and can cause a person's tyramine levels to become too high, which can be extremely dangerous. Although orally disintegrating selegiline is "selective" for MAO-B, it can inhibit MAO-A to some extent, especially at higher doses.

When and How to Take Orally Disintegrating Selegiline

General considerations for when and how to take orally disintegrating selegiline include the following:
  • The medication comes in the form of an orally disintegrating tablet. It is taken by mouth once a day, in the morning before breakfast.
  • Gently peel back the foil of the blister pack (do not try to push the delicate tablet through the foil). With dry hands, place the tablet on your tongue, where it will immediately dissolve.
  • Do not eat or drink for five minutes before or after taking an orally disintegrating selegiline tablet.
  • Make sure to take orally disintegrating selegiline at the same time each day to maintain an even level in your blood.
  • For the medication to work properly, it must be taken as prescribed. Orally disintegrating selegiline will not work if you stop taking it. Do not suddenly stop taking the drug without first talking to your healthcare provider.
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