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Drug Interactions With Orally Disintegrating Selegiline

You should not take orally disintegrating selegiline with certain medicines, as it could cause potentially serious drug interactions. With orally disintegrating selegiline, interactions may occur if this medication is taken with certain antidepressants; pressor medications; and cough, cold, or allergy medications, among other things. Before using orally disintegrating selegiline, tell your healthcare provider about all other medications you are taking to reduce your chance of negative drug interactions.

Drug Interactions With Orally Disintegrating Selegiline: An Overview

Orally disintegrating selegiline (Zelapar®) can potentially interact with many medications. Because so many drug interactions with orally disintegrating selegiline can be dangerous, it is important to check with your healthcare provider before combining orally disintegrating selegiline with any other medicine, regardless of whether it is a prescription or over-the-counter medicine.
Make sure to tell all your healthcare providers (including dentists and surgeons) that you are taking orally disintegrating selegiline. Some of the medicines that may lead to drug interactions with orally disintegrating selegiline include:


  • Other monoamine oxidase inhibitors (MAOIs), such as:
    • Dopamine
    • Ephedrine
    • Epinephrine (Adrenalin®, EpiPen®)
    • Isometheptene (Duradrin®, Midrin®, Migquin®, Migratine®, Migrazone®, Migrin-A®)
    • Levonordefrin (Carbocaine with Neo-Cobefrin®)
    • Midodrine (Orvaten®, ProAmatine®)
    • Norepinephrine (Levophed®)
  • Stimulants, such as:
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