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Drug Interactions With Orally Disintegrating Carbidopa-Levodopa

Monoamine Oxidase Inhibitors (MAOIs)
Nonselective MAOIs (isocarboxazid, phenelzine, and tranylcypromine) should not be combined with orally disintegrating carbidopa-levodopa or used within two weeks of using orally disintegrating carbidopa-levodopa. Selective MAOI-B inhibitors (selegiline and rasagiline) can be used with orally disintegrating carbidopa-levodopa, although they may increase the risk of low blood pressure.
 
Phenytoin (Dilantin, Phenytek)
Phenytoin can make orally disintegrating carbidopa-levodopa less effective. Check with your healthcare provider before taking these medications together.
 
Tricyclic Antidepressants
There have been reports of occasional problems (such as high blood pressure or involuntary body movements) when orally disintegrating carbidopa-levodopa was combined with a tricyclic antidepressant. Check with your healthcare provider before combining orally disintegrating carbidopa-levodopa with a tricyclic antidepressant.
 

Final Thoughts on Drug Interactions With Orally Disintegrating Carbidopa-Levodopa

It is possible that not all orally disintegrating carbidopa-levodopa drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific drug interactions that may apply to you.
 
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Info on Orally Disintegrating Carbidopa-Levodopa

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