Nuedexta helps treat pseudobulbar affect (PBA) in people who are at least 18 years old. Specifically, this medicine has been shown to reduce uncontrollable laughing and crying outbursts in people with Lou Gehrig's disease or multiple sclerosis. It is not exactly clear how this drug works, but it is known to affect certain receptors in the brain. There are currently no unapproved ("off-label") uses for Nuedexta.
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Nuedexta™ (dextromethorphan and quinidine) is a prescription medication approved for the treatment of pseudobulbar affect (PBA).
PBA is a condition characterized by sudden episodes of involuntary, uncontrolled crying or laughing. These episodes occur even though there does not seem to be anything to laugh or cry about.
People with PBA have certain nervous system diseases or injuries that damage the area of the brain responsible for controlling the normal expression of emotions. Nervous system conditions that are associated with PBA include but are not limited to:
- Lou Gehrig's disease, or amyotrophic lateral sclerosis (ALS)
- Multiple sclerosis (MS)
- Parkinson's disease
- Traumatic brain injury (TBI).
Nuedexta has been shown to reduce crying and laughing outbursts in people with PBA. The effectiveness of this medicine for PBA treatment was studied in people with ALS and multiple sclerosis. It is unknown if the medication works to treat PBA associated with other conditions.
Although Nuedexta may work well for some people, not everyone will respond to the medication. Talk to your healthcare provider if your symptoms do not seem to improve or get worse while you are taking this medication.
Additionally, PBA will sometimes improve on its own, even without medication. Therefore, your healthcare provider may periodically take you off Nuedexta to see if you still need it.