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Nuedexta Uses

How Does Nuedexta Work?

The exact way Nuedexta works to treat pseudobulbar affect is unknown. Dextromethorphan, one of the medicines in Nuedexta, is known to work in the brain. It is commonly found in cough and cold products, because it has actions in the "cough center" of the brain, where it suppresses coughing.
 
Dextromethorphan blocks N-methyl-D-aspartate receptors (more commonly called NMDA receptors), preventing the action of glutamate, an excitatory brain chemical. It also binds to sigma receptors. The role of sigma receptors in the brain is not clearly established, but researchers believe they may play a role in certain neurological conditions.
 
Quinidine, the other medication in Nuedexta, slows down the rate at which the body breaks down dextromethorphan. This increases dextromethorphan blood levels, increasing dextromethorphan's effect in the body.
 

Can Children Use Nuedexta?

This drug is not approved for use in people younger than 18 years of age, as it has not been adequately studied in this age group.
 

Can Older Adults Use It?

This medication may be used in older adults. However, because only a small number of older adults were included in clinical trials, it is unknown whether older adults will respond differently than younger age groups. Also, older adults may be more sensitive to some of the side effects of this medication.
 

Is Nuedexta Used for Off-Label Reasons?

On occasion, your healthcare provider may recommend this medicine for treating something other than PBA. This would be known as an "off-label" use. However, at this time, there are no universally accepted off-label uses for Nuedexta.
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Nuedexta Medication Information

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