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Nuedexta Drug Interactions

P-Glycoprotein (Pgp) Inhibitors
P-glycoprotein (Pgp) is a protein found in the body. One of its roles is to help remove substances, such as medications, out of the tissues so they can be excreted through the urine or feces. Pgp helps remove Nuedexta from the body. Certain other medications (known as Pgp inhibitors) decrease the activity of Pgp.
Taking Nuedexta with one of these Pgp inhibitors causes Nuedexta to be removed more slowly, potentially increasing the amount of Nuedexta in your body and increasing your risk for serious side effects. Your healthcare provider may choose to monitor you more closely for side effects if you take Nuedexta with a Pgp inhibitor.
Nuedexta may increase the amount of paricalcitol in your blood, which may increase your risk for side effects. Your healthcare provider may choose to monitor you parathyroid hormone, calcium, and phosphorus levels (with simple blood tests) if you take these medications together.
Nuedexta may increase pazopanib blood levels, which could increase the risk for potentially dangerous side effects. In general, these medications should not be used together. If a healthcare provider recommends you take pazopanib with Nuedexta, he or she may give you a lower pazopanib dose.
Nuedexta contains quinidine, and should not be used in combination with quinidine or any other medications that contain quinidine.
Taking Nuedexta with an SSRI or SNRI medications can increase your risk for a serious reaction known as serotonin syndrome (see Nuedexta Warnings and Precautions for more information, including symptoms of serotonin syndrome). Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome.
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Nuedexta Medication Information

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