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Nuedexta Drug Interactions

QT-Prolonging Medications
Nuedexta can cause QT prolongation, a potentially dangerous heart rhythm problem. In general, Nuedexta should not be combined with any other medications that can cause QT prolongation, due to the risk of a life-threatening arrhythmia.
 
Methylprednisolone
Nuedexta can increase methylprednisolone blood levels, increasing the risk for potentially serious side effects. If you take these medications together, your healthcare provider may lower your methylprednisolone dose and monitor you more closely.
 
Mometasone Inhaler
Normally, only a small amount of inhaled mometasone is absorbed into the body. However, when used with Nuedexta, mometasone blood levels may increase. This could increase your risk for side effects. Your healthcare provider may choose to monitor you more closely if you take these medications together.
 
Monoamine Oxidase Inhibitors (MAOIs)
Taking Nuedexta with MAOIs can increase your chance of developing a potentially life-threatening problem known as serotonin syndrome. Do not take Nuedexta if you have taken an MAOI within the past two weeks. Also, wait two weeks after stopping Nuedexta before taking an MAOI.
 
Neuromuscular-Blocking Medications
There have been cases of increased neuromuscular-blocking effects, such as decreased breathing, in people taking quinidine (one of the active ingredients in Nuedexta) who also received a neuromuscular-blocking medication. Neuromuscular-blocking agents are normally used during surgery. If you are taking Nuedexta and have an upcoming surgery, discuss this with your healthcare provider.
 
P-Glycoprotein (Pgp) Inducers
P-glycoprotein (Pgp) is a protein found in the body. One of its roles is to help remove substances, such as medications, out of body tissues so they can be excreted through the urine or feces. Pgp helps remove Nuedexta from the body. Certain other medications (known as Pgp inducers) increase the activity of Pgp.
 
Taking Nuedexta with one of these Pgp inducers causes Nuedexta to be removed from the body too quickly, potentially making it less effective. Your healthcare provider may choose to monitor you more closely if you take Nuedexta with a Pgp inducer, to make sure it is working for you.
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Nuedexta Medication Information

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