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Mysoline Side Effects
Although most people do not experience any problems while taking Mysoline, side effects can occur during treatment with the medication. The most common Mysoline side effects include coordination problems and spinning sensations (vertigo). Some of the more serious side effects of Mysoline include depression, unusual bleeding or bruising, or seizures that are getting worse. If you experience any of these serious side effects, it's important to notify your healthcare provider right away.
As with any medicine, side effects are possible with Mysoline® (primidone). However, not everyone who takes the medication will experience side effects. In fact, most people tolerate Mysoline quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Mysoline. Your healthcare provider can discuss a more complete list of Mysoline side effects with you.)
Mysoline is an older seizure medication, approved many years ago. With newer medications, side effects are carefully documented, and the exact percentage of people that develop each side effect is known. With older medications, like Mysoline, the information on side effects is less specific, and exact percentages are not reported.
The most common side effects of Mysoline (especially in people first starting the medication) include:
- Coordination problems
- A spinning sensation (vertigo).
In general, the side effects listed above usually improve with time. Other common side effects include:
- Nausea, vomiting, or appetite loss
- Fatigue
- Irritability
- Impotence (also known as erectile dysfunction or ED)
- Double vision or unusual eye movements
- Drowsiness.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD




