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Machado-Joseph Disease

Type I
Type I Machado-Joseph disease is characterized by:
  • Affecting people between 10 and 30 years of age
  • A fast progression
  • Severe dystonia and rigidity.
Type II
Type II Machado-Joseph disease is characterized by:
  • Affecting people between 20 and 50 years of age
  • An intermediate progression
  • Symptoms that include spasticity (continuous, uncontrollable muscle contractions), spastic gait, and exaggerated reflex responses.
Type III
Type III Machado-Joseph disease is characterized by:
  • Affecting patients between 40 and 70 years of age
  • A relatively slow progression
  • Some muscle twitching or muscle atrophy
  • Unpleasant sensations such as numbness, tingling, cramps, and pain in the hands, feet, and limbs.
Other common symptoms of Machado-Joseph disease include:
  • Vision problems, including double vision (diplopia) or blurred vision
  • Loss of ability to distinguish color and/or contrast
  • Inability to control eye movements.
Some patients with Machado-Joseph disease also experience Parkinson's-like symptoms, such as slowness of movement, rigidity or stiffness of the limbs and trunk, tremor or trembling in the hands, and impaired balance and coordination.
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