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Common Vigabatrin Side Effects in Younger Children
In the studies of vigabatrin in young children (infants to two years of age), no placebo was used. This was probably for ethical reasons, as vigabatrin is used to treat a very serious form of epilepsy in young children. Therefore, it is difficult to know for sure if some of the reported side effects are really related to vigabatrin use.
For instance, a large percentage of children taking this medicine developed an upper respiratory tract infection (a cold). However, these infections are quite common in young children, and it is possible that this reported side effect has nothing at all to do with the medication.
Common side effects of vigabatrin in young children age one month to two years old included:
- Upper respiratory tract infections (such as the common cold) -- in up to 51 percent of children
- Inflammation in the middle ear (a sign of an ear infection) -- up to 44 percent
- At least some degree of permanent vision loss -- in "at least 30 percent of people" (exact percentage was not provided)**
- Fever -- up to 29 percent
- Irritability -- up to 23 percent
- Viral infection -- up to 20 percent
- Vomiting -- up to 20 percent
- Drowsiness -- up to 19 percent.
(**This data on permanent vision loss comes from studies of the drug in adults. Because it is difficult to measure vision loss in young children, the exact data for vision loss in children is not available. However, vision loss is expected to be quite common in children, as it is in adults.)
Some of these common side effects are also potentially serious and should be reported to your healthcare provider.
Other common side effects in children, occurring in 10 percent to 16 percent of young children, included: