Nervous System Home > Drug Interactions With Sumatriptan

There are many sumatriptan drug interactions to be aware of. For example, taking sumatriptan along with certain antidepressants can cause a group of symptoms called serotonin syndrome. A few of these symptoms include confusion, hallucinations, diarrhea, and difficulty walking. Other drug interactions with sumatriptan can raise the level of sumatriptan in your blood or increase your risk of dangerous side effects, among other things. Ergot medications and triptans are also among the drugs that can potentially interact with sumatriptan.

Drug Interactions With Sumatriptan: An Overview

Sumatriptan succinate (Alsuma™, Imitrex®, Sumavel®, Zecuity™) can potentially interact with many drugs. Some of the drugs that may lead to sumatriptan interactions include:
  • Monoamine oxidase inhibitors (MAOIs), such as:
  • Ergot medications, such as:


    • Bromocriptine (Parlodel®)
    • Dihydroergotamine (Migranal®)
    • Ergotamine (Bellamine-S®, Cafergot®, Ergomar®)
    • Pergolide (Permax®)



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Last reviewed by: Kristi Monson, PharmD;
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