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Interactions With Sumatriptan Explained

The following sections explain in detail the potentially negative interactions that can occur when sumatriptan is combined with any of the drugs listed above.
Certain Antidepressants
Taking sumatriptan with certain depression medications can cause a group of symptoms called serotonin syndrome. These symptoms include:
  • Confusion
  • Hallucination
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.
Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.
There are special warnings for MAOIs. Taking sumatriptan with a type A MAOI can greatly increase the amount of sumatriptan in your blood, increasing your chance of dangerous sumatriptan side effects. Do not take sumatriptan if you have used a type A MAOI within the last two weeks. Although selegiline and rasagiline are usually considered to be type B MAOIs, they may also be MAO-A inhibitors when used at high doses. Ask your healthcare provider before taking sumatriptan with selegiline or rasagiline.
Ergot Medications
Taking sumatriptan with ergot medications can increase your risk of dangerous side effects. Do not take sumatriptan and ergot medications within 24 hours of each other.
Taking sumatriptan with other triptans can increase your risk of serious side effects. These medications should not be taken within 24 hours of each other.

Drug Interactions With Sumatriptan: Summary

It is possible that not every sumatriptan drug interaction was discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about specific drug interactions with sumatriptan that may apply to you.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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