Nervous System Home > Mysoline Warnings and Precautions

Prior to taking a new medication, it is important to understand the risks involved with taking it. With Mysoline, warnings and precautions relate to issues such as possible drug interactions, the safety of taking the drug when pregnant or breastfeeding, and the risk of potential side effects of the drug. You should not take Mysoline if you are allergic to any of the ingredients used to make the medication.

Mysoline: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Mysoline® (primidone) if you have:
  • Porphyria
  • Anemia or any other blood disorder
  • Any allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Mysoline Warnings and Precautions

Warnings and precautions to be aware of prior to taking Mysoline include the following:
  • Seizure medications, including Mysoline, may increase the risk of suicidal thoughts or behavior. Let your healthcare provider know immediately if you feel depressed or have any suicidal thoughts (see Seizure Medications and Suicide for more information).


  • Mysoline can cause drowsiness and problems with coordination. Be sure to tell your healthcare provider if you develop any of these Mysoline side effects, especially if they are severe and do not improve with time. Also, make sure to see how Mysoline affects you before driving or operating any machinery.
  • As with all seizure medications, Mysoline should not be stopped too quickly (see Primidone Withdrawal).
  • There have reports of certain blood problems in people taking Mysoline. It appears that Mysoline can sometimes decrease the bone marrow's ability to produce blood cells. Let your healthcare provider know if you have any unusual bruising or bleeding or frequent infections.
  • Mysoline can interact with other medications (see Mysoline Drug Interactions).
  • Mysoline is considered a pregnancy Category D medication. This means that it is probably not safe for use in pregnant women. Talk to your healthcare provider about the risks and benefits of taking the drug during pregnancy (see Primidone and Pregnancy).
  • Mysoline passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, discuss this with your healthcare provider prior to taking the drug (see Primidone and Breastfeeding).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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