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- A bile duct obstruction or gallbladder disease
- Lung problems, such as asthma or chronic obstructive pulmonary disease (COPD)
- Kidney disease, such as kidney failure (renal failure)
- Liver disease, such as liver failure, cirrhosis, or hepatitis
- Any allergies, including allergies to foods, dyes, or preservatives.
- Pregnant or thinking of becoming pregnant (see Comtan and Pregnancy)
- Breastfeeding (see Comtan and Breastfeeding).