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What If I Overdose on Clobazam?

An overdose with this medication can cause serious problems. Seek immediate medical attention if you or someone else may have overdosed on this medication.
 
(Click Onfi Overdose for more information.)
 

What If I Miss a Dose?

If you miss a dose, take it as soon as you remember, unless it is almost time for the next dose. In this case, you should simply skip the missed dose and continue with your regular schedule. Do not take a double dose.
 

How Does It Work?

Clobazam belongs to a group of medications called benzodiazepines. Benzodiazepines have various effects on the body, such as:
 
  • Reducing anxiety
  • Causing sleepiness
  • Relaxing muscles
  • Stopping seizures
  • Impairing short-term memory.
 
All benzodiazepines can have these effects to some degree, depending on the specific benzodiazepine that is being taken. They work in the brain by enhancing the effects of gamma-aminobutyric acid (GABA), a brain chemical that is naturally calming. GABA can slow down or stop certain nerve signals in the brain. This is why clobazam and other benzodiazepines are known as mild tranquilizers, sedatives, or central nervous system depressants (CNS depressants).
 

Clinical Effects of Clobazam

This medication has been thoroughly evaluated in clinical studies. These studies looked at clobazam in people with Lennox-Gastaut syndrome whose seizures were not adequately controlled with their current medications. In one study, adding clobazam significantly reduced seizure frequency by up to 68.3 percent (depending on the dose), compared to only 12.1 percent for those who were given a placebo (a "sugar pill" that does not contain any active ingredients) in addition to their regular seizure medications.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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