Nervous System Home > Carbidopa-Levodopa

Drug Interactions

Carbidopa-levodopa can potentially interact with a number of other medicines (see Drug Interactions With Carbidopa-Levodopa).
 

What If I Take an Overdose?

People who take too much carbidopa-levodopa may experience symptoms such as:
 
If you happen to overdose on this drug, seek immediate medical attention.
 
(Click Sinemet Overdose for more information.)
 

How Should Carbidopa-Levodopa Be Stored?

Carbidopa-levodopa tablets should be stored at room temperature, away from moisture, heat, and light. Keep this and all other medications out of the reach of children.
 

What Should I Do If I Miss a Dose?

If you forget to take a dose of carbidopa-levodopa, take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and continue with your regular schedule. Do not take a double dose.
 

How Does This Medication Work?

Dopamine deficiency, caused by a loss of dopamine-producing cells in certain parts of the brain, may be responsible for many of the symptoms of Parkinson's disease. Although it would make sense to give dopamine to help treat Parkinson's, this does not work, as dopamine cannot cross the blood-brain barrier.
 
Levodopa is a precursor of dopamine, which means that the body can use it to make dopamine. Unlike dopamine, levodopa crosses the blood-brain barrier.
 
Levodopa is almost always given in combination with carbidopa. Carbidopa delays the conversion of levodopa into dopamine until it reaches the brain, preventing or diminishing some of the side effects that often accompany levodopa therapy. Carbidopa also reduces the amount of levodopa needed for Parkinson's disease treatment.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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