Carbidopa-levodopa-entacapone is a prescription drug licensed for the treatment of Parkinson's disease. It contains three different medications:, one that is the "real" drug used to treat Parkinson's and two that are used to help it work better and longer. Carbidopa-levodopa-entacapone comes in tablet form and is generally taken three or four times daily. Potential side effects include nausea, diarrhea, and urine discoloration.
To substitute for carbidopa-levodopa (Sinemet®) plus entacapone (Comtan®) in people already taking these medications
To replace carbidopa-levodopa in people experiencing "wearing-off" symptoms (when the medication stops working before the next dose) who take 600 mg of levodopa per day or less and who are not experiencing dyskinesia (a movement disorder that is a side effect of carbidopa-levodopa).
As with any medicine, side effects are possible with carbidopa-levodopa-entacapone. Most people tolerate it relatively well at first, especially if the dose is increased slowly. If side effects do occur, in many cases, they are minor and either require no treatment or can be easily treated by you or your healthcare provider. As time goes by, it is common for more bothersome and serious side effects of carbidopa-levodopa-entacapone to occur.
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