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Lioresal Warnings and Precautions

To help ensure safe treatment with Lioresal, warnings and precautions for the drug should be reviewed with your healthcare provider. For example, it is important to know that Lioresal may increase the risk of seizures and can make certain mental illnesses worse. Safety concerns also apply to people who have certain allergies and to women who are pregnant or breastfeeding.

What Should I Tell My Healthcare Provider Before Taking Lioresal?

You should talk with your healthcare provider prior to taking Lioresal® (baclofen) if you have:
  • Kidney disease, such as kidney failure (renal failure)
  • Epilepsy or a history of seizures
  • A history of stroke
  • Mental illness of any kind
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Lioresal Warnings and Precautions

Warnings and precautions to be aware of prior to taking Lioresal include the following:
  • Stopping Lioresal too quickly (for any reason) can lead to withdrawal symptoms (see Baclofen Withdrawal).
  • This medication could increase the risk of seizures, particularly in people with seizure disorders.
  • Lioresal does not appear to be useful in people who have had a stroke. In addition, these individuals often seem less able to tolerate the drug.
  • Lioresal usually causes drowsiness. It can also cause dizziness or confusion. Make sure you know exactly how it affects you before driving a car or operating heavy machinery.
  • This medication may increase the risk of ovarian cysts.
  • If you receive Lioresal through a pump (to deliver the medication directly to the spinal cord), your healthcare provider should take extreme precautions when adjusting your dosage or refilling the pump in order to avoid an accidental overdose. Your healthcare provider must be prepared in case of an emergency situation.
  • Tell your healthcare provider if you have kidney disease, as you may need a lower Lioresal dosage.
  • There have been reports of Lioresal causing a worsening of various mental illnesses. Your healthcare provider should monitor you for any signs of such problems.
  • Lioresal can interact with other medications (see Lioresal Drug Interactions).
  • Lioresal is considered a pregnancy Category C medication. This means that it might not be safe for use during pregnancy, although the full risks are currently unknown. Talk to your healthcare provider about the risks and benefits of taking this drug when pregnant (see Baclofen and Pregnancy).
  • Lioresal passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Baclofen and Breastfeeding).
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Lioresal Drug Information

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