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Lioresal Drug Interactions
If you combine alcohol, sleep medications, or antidepressants with Lioresal, drug interactions may occur. Combining it with any medication that causes drowsiness or sedation may increase the risk of severe drowsiness, confusion, or dizziness. To reduce the risk of drug interactions, talk with your healthcare provider about any other medications you are taking, including your daily consumption of alcohol.
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Lioresal Interactions: An Overview
- Alcoholic beverages (or other products that contain alcohol)
- Antidepressant medications
- Antihistamines (including many nonprescription cold, cough, allergy, motion sickness, and sleep medications)
- Antipsychotics, such as:
- Aripiprazole (Abilify®)
- Asenapine (Saphris®)
- Chlorpromazine (Thorazine®)
- Clozapine (Clozaril®, FazaClo®)
- Fluphenazine (Prolixin®)
- Haloperidol (Haldol®)
- Iloperidone (Fanapt®)
- Loxapine (Adasuve™, Loxitane®)
- Lurasidone (Latuda®)
- Molindone (Moban®)
- Olanzapine (Zyprexa®, Symbyax®)
- Paliperidone (Invega®)
- Perphenazine (Trilafon®)
- Pimozide (Orap®)
- Prochlorperazine (Compazine®, Compro®)
- Quetiapine (Seroquel®)
- Risperidone (Risperdal®)
- Thioridazine (Mellaril®)
- Thiothixene (Navane®)
- Trifluoperazine (Stelazine®)
- Ziprasidone (Geodon®)
- Barbiturates, such as:
- Amobarbital (Amytal®)
- Butalbital (Fioricet®, Fiorinal®)
- Pentobarbital (Nembutal®)
- Phenobarbital (Luminal®)
- Secobarbital (Seconal®)
- Benzodiazepine sedatives, such as:
- Alprazolam (Xanax®, Xanax XR®)
- Chlordiazepoxide (Librium®, Limbitrol®, Librax®)
- Clonazepam (Klonopin®)
- Clorazepate (Tranxene®)
- Diazepam (Valium®)
- Estazolam (ProSom®)
- Flurazepam (Dalmane®)
- Lorazepam (Ativan®)
- Midazolam (Versed®)
- Temazepam (Restoril®)
- Triazolam (Halcion®)
- Muscle relaxants, such as:
- Carisoprodol (Soma®)
- Chlorzoxazone
- Cyclobenzaprine (Flexeril®, Amrix®)
- Dantrolene (Dantrium®)
- Metaxalone (Skelaxin®)
- Monoamine oxidase inhibitors (MAOIs), such as:
- Isocarboxazid (Marplan®)
- Phenelzine (Nardil®)
- Rasagiline (Azilect®)
- Selegiline (Eldepryl®, Emsam®, Zelapar®)
- Tranylcypromine (Parnate®)
- Narcotics or opiates, such as hydrocodone/APAP (Lortab®, Vicodin®, and others) or oxycodone (OxyIR®, OxyContin®)
- Sleep medications.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD