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Drug Interactions With Lacosamide

Lacosamide Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur due to lacosamide drug interactions.
 
Carbamazepine
Some studies suggest that carbamazepine may slightly decrease the level of lacosamide in the blood, although this is not expected to cause significant problems.
 
CYP 2C9 Inhibitors
Lacosamide is broken down by various liver enzymes, including a group known as CYP 2C9 enzymes. Medications that make these enzymes less active are known as CYP 2C9 inhibitors. Such drugs may increase the level of lacosamide in the blood, especially in people with liver or kidney problems. A lower-than-normal lacosamide dosage may be necessary in some cases.  
 
CYP 3A4 Inhibitors
Lacosamide is broken down by various liver enzymes, including a group known as CYP 3A4 enzymes. Medications that make these enzymes less active are known as CYP 3A4 inhibitors. Such drugs may increase the level of lacosamide in the blood, especially in people with liver or kidney problems. A lower-than-normal lacosamide dosage may be necessary in some cases.  
 
Phenobarbital
Some studies suggest that phenobarbital may slightly decrease the level of lacosamide in the blood, although this is not expected to cause significant problems.
 
Phenytoin
Some studies suggest that phenytoin may slightly decrease the level of lacosamide in the blood, although this is not expected to cause significant problems.
 

Final Thoughts

It is possible that not all drug interactions with lacosamide were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific lacosamide drug interactions that may apply to you.
 
Know the Signs - Concussion Safety

Lacosamide Drug Information

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