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Kemadrin Drug Interactions
There are several medications that may negatively interact with Kemadrin. Drug interactions may occur if Kemadrin is taken with other anticholinergic medications, antipsychotics, and tricyclic antidepressants, to name a few. Some of these Kemadrin drug interactions can decrease the effectiveness of the medications or increase your risk of developing side effects (such as severe constipation, difficulty passing urine, or dry eyes).
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Kemadrin® (procyclidine hydrochloride) can potentially interact with several different medications. Some of the medicines that may lead to Kemadrin drug interactions include:
- Acetylcholinesterase inhibitor medications, such as:
- Donepezil (Aricept®)
- Galantamine (Razadyne™)
- Rivastigmine (Exelon®, Exelon® Patch)
- Tacrine (Cognex®)
- Antipsychotic medications
- Other anticholinergic drugs, such as:
- Atropine
- Belladonna (Donnatal®, B&O Supprettes®)
- Benztropine (Cogentin®)
- Clidinium (Librax®)
- Clozapine (Clozaril®)
- Darifenacin (Enablex®)
- Dicyclomine (Bentyl®)
- Diphenhydramine (Benadryl®, Tylenol PM®)
- Glycopyrrolate (Robinul®)
- Haloperidol (Haldol®)
- Homatropine (Hycodan®)
- Hyoscyamine (Levsin®)
- Ipratropium (Atrovent®)
- Oxybutynin (Ditropan®, Ditropan XL®, Oxytrol®)
- Solifenacin (VESIcare®)
- Scopolamine (Transderm Scop®)
- Tiotropium (Spiriva®)
- Tolterodine (Detrol®, Detrol® LA)
- Trihexyphenidyl (Artane®)
- Trospium (Sanctura®, Sanctura® XR)
- Pramlintide (Symlin®)
- Tricyclic antidepressants, including:
- Amitriptyline (Elavil®)
- Amoxapine (Asendin®)
- Clomipramine (Anafranil®)
- Desipramine (Norpramin®)
- Doxepin (Sinequan®, Silenor®)
- Imipramine (Tofranil®, Tofranil PM®)
- Maprotiline (Ludiomil®)
- Nortriptyline (Pamelor®)
- Protriptyline (Vivactil®)
- Trimipramine (Surmontil®).
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD



