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What Is Felbamate Used For?

Using Felbamate for Partial Seizures

Seizures are caused by brief surges of electrical activity in the brain. The symptoms of a seizure vary, depending on the type, and can affect the senses, emotions, body movements, or consciousness (see Epilepsy Symptoms). While there are many different types of seizures, a person with epilepsy will often have the same type and experience the same symptoms.
 
Seizures are usually divided into two common types: partial seizures and generalized seizures (see Types of Seizures). The main difference between the two is where they start. Partial seizures start in one area of the brain, while generalized seizures occur in both sides of the brain. Sometimes, partial seizures start in one part of the brain and then spread throughout the brain to become generalized seizures.
 
Felbamate has been shown to reduce partial seizures in adults with epilepsy when used alone or in combination with other seizure medications. It can be used to prevent partial seizures that do not become generalized, as well as those that do become generalized.
 

Using Felbamate for Lennox-Gastaut Syndrome in Children

Lennox-Gastaut syndrome is a severe type of epilepsy that usually starts in children younger than four years old. It is often associated with intellectual disability. Although there are many causes of Lennox-Gastaut syndrome, in 30 to 35 percent of cases, the cause is unknown.
 
Seizures due to Lennox-Gastaut syndrome are often difficult to treat. The types of seizures associated with this condition include:
 
  • Tonic (stiffening of the body, upward deviation of the eyes, dilation of the pupils, and altered respiratory patterns)
  • Atonic (brief loss of muscle tone and consciousness, causing abrupt falls)
  • Atypical absence (staring spells)
  • Myoclonic (sudden muscle jerks).
 
Felbamate has been shown to decrease the number of seizures in children with Lennox-Gastaut syndrome when it is combined with other seizure medications.
 
In a clinical study, children who were taking one or two other seizure medications but still experiencing at least 90 seizures a month were given either felbamate or a placebo (a "sugar pill") in addition to their other seizure medications. Children who received the felbamate had a 26 percent decrease, on average, in their number of seizures over 70 days. In comparison, children who were given the placebo had a 5 percent increase in seizures, on average.
 
Know the Signs - Concussion Safety

Felbamate Drug Information

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