What Is Ezogabine Used For?
If you have partial-onset seizures, your healthcare provider may prescribe ezogabine. It is used in combination with other seizure medications and is believed to work by opening up the potassium channels in the brain. This helps control seizures by preventing abnormal electrical activity from spreading in the brain. Unapproved uses for ezogabine include treating other types of seizures.
Ezogabine (Potiga™) is a prescription seizure medication. Specifically, it is approved for use in combination with other seizure medications to treat partial-onset seizures in adults age 18 and older.
There are over 30 different types of seizures a person with epilepsy may experience. These seizures are generally classified into two main categories: partial-onset seizures (also known as focal seizures or simply partial seizures) and generalized seizures.
Partial seizures occur in just one part of the brain. Two types of partial-onset seizures are:
- Simple partial seizures, in which a person will remain conscious but experiences unusual feelings or sensations that can take many forms.
- Complex partial seizures, in which a person has a change or loss of consciousness. People having a complex partial seizure may display strange, repetitious behaviors such as blinks, twitches, mouth movements, or even walking in a circle.
A seizure can start out as a partial seizure before turning into a generalized seizure (this is known as secondary generalization). Generalized seizures are a result of abnormal brain activity on both sides of the brain. These seizures may cause loss of consciousness, falls, or massive muscle spasms. The two most common forms are absence seizures (also known as petit mal seizures) and tonic-clonic seizures (grand mal seizures).
As is typical with new seizure medications, ezogabine is not to be used alone, as it has not been adequately studied for such use. In studies, people were given either ezogabine or a placebo (a "sugar pill" that does not contain any active ingredients) to take in addition to their usual seizure medications (it would be unethical to give a person with epilepsy just a placebo without the other medications).